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Co-localization of a protein involved in actin dynamics with F-actin during epithelial to mesenchymal (EMT) transition of mouse lens epithelial explant. Image taken by Sheardown Lab.
Contact Lenses
Drug Delivery

DESIGNING NOVEL POLYMER BIOMATERIALS FOR OCULAR APPLICATION

As Chemical Engineers, polymer chemistry is in our blood. Our vast knowledge allows us to design and synthesize original formulations that can prolong ocular residence time, increase tissue permeation, and deliver that vital cargo to where it needs to go.

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Liu L, Rambarran T, Muirhead B, Lasowski F, Sheardown H. A radiolabeling method for precise quantification of polymers. Bioconj Chem. 33:634-42 (2022).

https://pubs.acs.org/doi/10.1021/acs.bioconjchem.2c00047

Polymer Chemistry
This image is of retina cells showing the retinal layers.

CREATING ANIMAL MODELS TO BETTER OUR UNDERSTANDING OF OCULAR PATHOLOGIES

Our expertise in animal modeling allows us to study a breadth of ocular disease states as well as test our novel ocular biomaterials in-vivo.

Capabilities:

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  • Imaging Techniques

    • Posterior Fundus​

    • Posterior Optical Coherence Tomography (OCT)

    • Posterior Fluorescein Angiography

    • Anterior Slit Lamp

    • Anterior OCT

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  • Metrics

    • Tear Osmolarity​

    • Tear Volume

    • Ocular Surface Staining

    • Histology

Animal Models

ACADEMIC COLLABORATIONS

Sheardown Lab is actively collaborating with many academic partners, including other researchers at McMaster University and the University of Waterloo. For further information on opportunities for collaboration and fees for service work, please refer to the C20/20 Innovation Hub.

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Academic Collaborations

INDUSTRY COLLABORATIONS

Invested in commercialization, we collaborate with industry partners to help products get to market. Some recent collaborations are shown below.

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