IMPROVING PATIENT COMFORT
WITH NEXT GENERATION
We are working on the next-generation of contact lenses capable of delivering drug effectively to the front of the eye to treat anterior ocular conditions. We are also improving upon the formulation of contact lenses to improve patient comfort. Working with industry partners, we are helping formulations reach market fast.
Liu L, Rambarran T, Sheardown H. Phenylboronic Acid Modified Hydrogel Materials and their Potential for Use in Contact Lens Based Drug Delivery. J Biomater Sci, Polym Ed June20 1-15 (2022). DOI: 10.1080/09205063.2022.2088531
Korogiannaki M, Samson M, Matheson A, Soliman K, Schmidt TA, Sheardown H. Investigating the synergistic interactions of surface immobilized and free natural ocular lubricants for contact lens applications: A comparative study between hyaluronic acid and proteoglycan 4 (Lubricin). Langmuir. 37: 1062-1072 (2021). DOI: 10.1021/acs.langmuir.0c02796
DELIVERING VISION SAVING THERAPEUTICS TO HARD TO REACH OCULAR TISSUE
Utilizing our expertise in drug delivery, we are developing novel methods for sustained drug delivery to ocular tissues through our patented technologies and biomedical modelling strategies.
Ross M, Hicks EA, Rambarran T, Sheardown H. Thermo-sensitivity and erosion of chitosan crosslinked poly[N-isopropylacrylamide-co-(acrylic acid)-co-(methyl methacrylate)] hydrogels for application to the inferior fornix. Acta Biomaterialia. 141:151-163 (2022). https://doi.org/10.1016/j.actbio.2022.01.043
Lasowski F, Rambarran T, Rahmani V, Brook MA, Sheardown H. PEG-Containing Siloxane Materials by Metal-Free Click-Chemistry for Ocular Drug Delivery Applications. J Biomater Sci, Polym Ed. 32(5):581-594. (2021). https://pubmed.ncbi.nlm.nih.gov/33187457/
DESIGNING NOVEL POLYMER BIOMATERIALS FOR OCULAR APPLICATION
As Chemical Engineers, polymer chemistry is in our blood. Our vast knowledge allows us to design and synthesize original formulations that can prolong ocular residence time, increase tissue permeation, and deliver that vital cargo to where it needs to go.
Liu L, Rambarran T, Muirhead B, Lasowski F, Sheardown H. A radiolabeling method for precise quantification of polymers. Bioconj Chem. 33:634-42 (2022).
Rambarran T, Sheardown H. Block Copolymer Synthesis using Free-Radical Polymerization and Thiol-Maleimide ‘Click’ Conjugation. RCS Advances 11;34631-34635 (2021). https://doi.org/10.1039/D1RA06089A
CREATING ANIMAL MODELS TO BETTER OUR UNDERSTANDING OF OCULAR PATHOLOGIES
Our expertise in animal modeling allows us to study a breadth of ocular disease states as well as test our novel ocular biomaterials in-vivo.
Posterior Optical Coherence Tomography (OCT)
Posterior Fluorescein Angiography
Anterior Slit Lamp
Ocular Surface Staining
Sheardown Lab is actively collaborating with many academic partners, including other researchers at McMaster University and the University of Waterloo. For further information on opportunities for collaboration and fees for service work, please refer to the C20/20 Innovation Hub.