Co-localization of a protein involved in actin dynamics with F-actin during epithelial to mesenchymal (EMT) transition of mouse lens epithelial explant. Image taken by Sheardown Lab.

IMPROVING PATIENT COMFORT 

WITH NEXT GENERATION 

CONTACT LENSES

We are working on the next-generation of contact lenses capable of delivering drug effectively to the front of the eye to treat anterior ocular conditions. We are also improving upon the formulation of contact lenses to improve patient comfort. Working with industry partners, we are helping formulations reach market fast.

Deng X, Korogiannaki M, Rastegari B, Zhang J, Chen M, Fu Q, Sheardown H, Filipe C, Hoare T. ‘Click’
Chemistry-Tethered Hyaluronic Acid-Based Contact Lens Coatings Improve Lens Wettability and Lower
Protein Adsorption
ACS Applied Materials and Interfaces. 8: 22064-22073 (2016).

Paterson SM, Liu L, Brook MA, Sheardown H. Poly (ethylene glycol) or silicone modified hyaluronon for
contact lens applications
.
J Biomed Mater Res 103: 2602-2610 (2015).

Samsom ML, Morrison S, Masala N, Sullivan BD, Sullivan DA, Sheardown H, Schmidt T. Characterization
of full-length recombinant human Proteoglycan 4 as an ocular surface boundary lubricant
.
Experimental
Eye Research 2014;127:14-9.

 

DELIVERING VISION SAVING THERAPEUTICS TO HARD TO REACH OCULAR TISSUE

Utilizing our expertise in drug delivery, we are developing novel methods for sustained drug delivery to ocular tissues through our patented technologies and biomedical modelling strategies.

Prosperi-Porta G, Muirhead B, Sheardown H. Tunable release of ophthalmic therapeutics from injectable, resorbable, thermoresponsive copolymer scaffolds. J Biomed Mater Res B 105: 53-62 (2017).

Jafar Mazumder MA, Fitzpatrick SD, Muirhead B, Sheardown H. Cell-adhesive thermo-gelling PNIPAAm /hyaluronic acid cell delivery hydrogels for non-invasive retinal therapeutics. J Biomed Mater Res A. 100:1877-1887 (2012).

Fitzpatrick SD, Mazumder MAJ, Lasowski F, Fitzpatrick LE, Sheardown H PNIPAAm-grafted collegen as
an injectable in situ gelling bioactive cell delivery scaffold
.
Biomacromolecules 11:2261-2267 (2010).

 

DESIGNING NOVEL POLYMER BIOMATERIALS FOR OCULAR APPLICATION

As Chemical Engineers, polymer chemistry is in our blood. Our vast knowledge allows us to design and synthesize original formulations that can prolong ocular residence time, increase tissue permeation, and deliver that vital cargo to where it needs to go.

Prosperi-Porta G, Kedzior S, Muirhead B, Sheardown H. Phenylboronic acid based polymeric micelles for mucoadhesive anterior segment ocular drug delivery Biomacromolecules 17:1449-1457 (2016).

Zhang J, Muirhead B, Dodd M, Liu L, Mangiacotte N, Xu F, Hoare TR, Sheardown H. An injectable
hydrogel prepared using a PEG/Vitamin E copolymer facilitating aqueous driven gelation
.
Biomacromolecules 17: 3648-3658 (2016).

 

 CREATING ANIMAL MODELS TO BETTER OUR UNDERSTANDING OF OCULAR PATHOLOGIES 

Our expertise in animal modeling allows us to study a breadth of ocular disease states as well as test our novel ocular biomaterials in-vivo.

Capabilities:

  • Imaging Techniques

    • Posterior Fundus​

    • Posterior Optical Coherence Tomography (OCT)

    • Posterior Fluorescein Angiography

    • Anterior Slit Lamp

    • Anterior OCT

  • Metrics

    • Tear Osmolarity​

    • Tear Volume

    • Ocular Surface Staining

    • Histology

 

ACADEMIC COLLABORATIONS

Sheardown Lab is actively collaborating with many academic partners, including other researchers at McMaster University and the University of Waterloo. For further information on opportunities for collaboration and fees for service work, please refer to the C20/20 Innovation Hub.

 

INDUSTRY COLLABORATIONS

Invested in commercialization, we collaborate with industry partners to help products get to market. Some current collaborations are shown below.

Mannin Research logo
This image is of ibi - Interface Biologics logo
GL Chemtec International logo
EyeGate Pharma logo