2020-
Jones L, Efron N, bandamwar K, Barnett M, Jacobs DS, et al. TFOS Lifestyle: Impact of contact lenses on the ocular surface. The Ocular Surface. Accepted 11 April 2023
Ross M, Sheardown H. Application of Thermogels to the Anterior of the Eye as Alternatives to Conventional Eyedrops. Advanced Therapeutics (2023). Accepted 27 Mar 2023
Ross M, Sheardown H. Thermo-responsive and mucoadhesive gels for the treatment of cystinosis. Biomaterials Advances. (2022). Accepted 1 Dec 2022. BIOADV-D-22-02643R2
Fitzpatrick SD, Mazumder J, Fitzpatrick L, Muirhead B, Boyd S, Rambarran T, Sheardown H. Synthesis of an Optically Transparent Poly(N-isopropylacrylamide) Based Thermally Gelling Material. Can J Chem. 101:2; (2022). https://cdnsciencepub.com/doi/abs/10.1139/cjc-2022-0187 https://doi.org/10.1139/cjc-2022-0187
Liu L, Rambarran T, Fitzpatrick S, Sheardown H. Phase Separation Control of PDMS/PNIPAAm IPNs and the Effect on Drug Release. https://doi.org/10.1016/j.polymer.2022.125323. Polymer. 259: (2022)
Lasowski F, Rambarran T, Rahmani V, Sheardown H. Tethered Drug Release from Model Contact Lenses. Polymer International. 72:99-105 (2022). https://onlinelibrary.wiley.com/doi/epdf/10.1002/pi.6450.
Tian J, Ross M, Liu L, Sheardown H. Hyaluronic Acid Based Therapeutic Bandage Contact Lenses for Corneal Wound Healing. Investigative Ophthalmology & Visual Science. 63: 3222-A0257 (2022). https://iovs.arvojournals.org/article.aspx?articleid=2782686
Liu L, Rambarran T, Sheardown H. Phenylboronic Acid Modified Hydrogel Materials and their Potential for Use in Contact Lens Based Drug Delivery. J Biomater Sci, Polym Ed June20 1-15 (2022). DOI: 10.1080/09205063.2022.2088531
Amaral N, Ross M, Taiyab A, Sheardown H. Delivery of Cells to the Cornea Using Synthetic Biomaterials. Cornea (2022). Accepted for publication 24 May 2022.
Liu L, Rambarran T, Muirhead B, Lasowski F, Sheardown H. A radiolabeling method for precise quantification of polymers. Bioconj Chem. 33:634-42 (2022).
Ross M, Hicks EA, Rambarran T, Sheardown H. Thermo-sensitivity and erosion of chitosan crosslinked poly[N-isopropylacrylamide-co-(acrylic acid)-co-(methyl methacrylate)] hydrogels for application to the inferior fornix. Acta Biomaterialia. 141:151-163 (2022).
Rambarran T, Sheardown H. Block Copolymer Synthesis using Free-Radical Polymerization and Thiol-Maleimide ‘Click’ Conjugation. RCS Advances 11; 34631-34635 (2021).
Taiyab A, Akula M, Dham J, Deschamps P, Sheardown H, Willliams T, Borras T, West-Mays J. Deletion of transcription factor AP-2β from the developing murine trabecular meshwork region leads to progressive glaucomatous changes. J Neurosci Res. (2021).
Goostrey T, Dave R, Ziolkowska M, Czerny-Holownia S, Hoare T, Sheardown H. Ocular drug delivery to the anterior segment using nanocarriers: a mucoadhesive/mucopenetrative perspective. J Control Release. 336: 71-88 (2021).
Battiston K, Parrag I, Statham M, Louka D, Fischer H, MacKey G, Daly A, Gu F, Muirhead B, Hicks EA, Sheardown H, Kalachev L, Crean C, Edelman J, Santerre JP, Naimark W. Polymer-free corticosteroid dimer implants for controlled and sustained drug delivery. Nat Commun 12:2875 (2021).
Rahmini V, Elshereef R, Sheardown H. Property Modelling of Lysozyme/Crosslinker-Alginate Complexes Using Latent Variable Methods. J Biomed Mater Res: Part A. 109:2225–2236 (2021).
Xu F, Lam A, Pan Z, Randhawa G, Lamb M, Sheardown H, Hoare T. Fast thermo-responsive poly(oligoethylene glycol methacrylate) (POEGMA)-based nanofibrous hydrogels for reversible tuning of cell interactions. ACS Biomater Sci Eng. 7:4258-4268 (2021).
Korogiannaki M, Samson M, Matheson A, Soliman K, Schmidt TA, Sheardown H. Investigating the synergistic interactions of surface immobilized and free natural ocular lubricants for contact lens applications: A comparative study between hyaluronic acid and proteoglycan 4 (Lubricin). Langmuir. 37: 1062-1072 (2021).
Liu P, Ryczko M, Xie X, Hicks EA, Taiyab A, Sheardown H, Quaggin S, Jin J. New soluble angiopoietin analog of Hepta-ANG1 prevents pathological vascular leakage. Biotechnol Bioeng 118:423-432 (2021).
Lasowski F, Rambarran T, Rahmani V, Brook MA, Sheardown H. PEG-Containing Siloxane Materials by Metal-Free Click-Chemistry for Ocular Drug Delivery Applications. J Biomater Sci, Polym Ed. 32(5):581-594. (2021).
Spadafora A, Korogiannaki M, Sheardown H. Anti-fouling silicone hydrogel contact lenses via densely grafted phosphorylcholine polymers. Biointerphases. 15; 041013 (2020).
Mangiacotte N, Prosperi-Porta G, Liu L, Dodd M, Sheardown H. Mucoadhesive Nanoparticlesfor Drug Delivery to the Anterior Eye. Nanomaterials 10; 1400:1-16 (2020).
Xu F, Gough I, Dorogin J, Sheardown H, Hoare TR. Nanostructured degradable macroporous hydrogel scaffolds with controllable internal morphologies via reactive electrospinning. Acta Biomater. 104:135-146 (2020).
2010-2019
Korogiannaki M, Jones L, Sheardown H. Impact of a hyaluronic acid grafted layer on the surface properties of a model silicone hydrogel contact lens. Langmuir 35: 950-961 (2019).
Postic I, Sheardown H. Altering the release of tobramycin by incorporating poly ethylene glycol into model silicone hydrogel contact lenses. J Biomaterials Science Polymer Edition 30:13; 1115-1141 (2019).
Hurtig M, Zaghoul I, Sheardown H, Schmidt TA, Liu LN, Zhang L, Elsaid KA, Jay GD
Two compartment pharmacokinetic model describes the intra-articular delivery and retention of rhprg4 following ACL transection in the Yucatan mini pig. J Ortho Res 37:2;386-396 (2019).
Xu F, Dodd M, Sheardown H, Hoare T. Single-Step Reactive Electrospinning of Cell-Loaded Nanofibrous Scaffolds as Ready-to-Use Tissue Patches. Biomacromolecues 19:11;4182-4192 (2018).
Postic I, Sheardown H. Poly (ethylene glycol) induces cell toxicity in melanoma cells by producing a hyperosmotic extracellular medium. J Biomaterials Applications 33: 693-706 (2018).
Korogiannaki M, Samsom M, Schmidt T, Sheardown H. Surface functionalized model contact lenses with a bioinspired proteoglycan 4 (PRG4)-grafted layer. ACS Applied Materials and Interfaces 10: 30125-30136. (2018).
Korgiannaki M, Jones L, Sheardown H. The impact of a hyaluronic acid-grafted layer on the surface properties of model silicone hydrogel contact lenses. Langmuir 35:4;950-961 (2018).
Jamard M, Sheardown H. Effect of methylcellulose molecular weight on the properties of self-assembling MC-g-PNtBAm nanogels. Bioengineering 5:2 (2018).
Xu F, Dodd M, Sheardown H, Hoare TR. Ready to use functional tissue patches via reactive electrospinning of cell loaded nanofibrous hydrogel scaffolds. Biomacromolecules (2018) 18: 4182-4192 (2018).
Rahmani V, Sheardown H. Protein alginate complexes as pH/ion sensitive carriers of proteins. Int J Pharm 535: 452-461 (2018).
Bakaic E, Smeets NMB, Badv M, Dodd M, Barrigar O, Siebers E, Lawlor M, Sheardown H, Hoare T. Injectable and degradable poly(oligoethylene glycol methacrylate) hydrogels with tunable charge densities as adhesive peptide-free cell scaffolds”. ACS Biomaterials Science & Engineering 4: 3713-3725 (2018).
Samsom M, Iwabuchi Y, Sheardown H, Schmidt T. Proteoglycan 4 and hyaluronan as boundary lubricants for model contact lens hydrogels. J Biomed Mater Res 106: 1329-1338. (2018).
Samsom M, Korogiannaki M, Subarraman L, Sheardown H, Schmidt T.. Hyaluronan incorporation into model contact lens hydrogels: Effect of hydrogel composition and proteoglycan 4 as a lubricant in solution. J Biomed Mater Res 106: 1818-1826 (2018).
Korogiannaki M, Zhang J, Sheardown H. Surface modification of model conventional hydrogel contact lenses with hyuraluronic acid via thiolene “click” chemistry. J Biomater Appl 32: 446-462 (2017).
Rahmani V, Elshereef R, Sheardown H. Optimizing electrostatic interactions for controlling the release of proteins from alginate and cationically modified alginate. Eur J Pharma Biopharm. 117: 232-243 (2017).
Rastergari B, Zenali S, Sheardown H, Karbelaei-Heidari HR. The enzyme-sensitive release of prodigiosin grafted β-cyclodextrin and chitosan magnetic nanoparticles as an anticancer drug delivery system: synthesis, characterization and cytotoxicity studies. Coll Surf B: Biointerfaces. 58: 589-601 (2017).
Zhang J, Muirhead B, Dodd M, Liu L, Mangiacotte N, Xu F, Hoare TR, Sheardown H. An injectable hydrogel prepared using a PEG/Vitamin E copolymer facilitating aqueous driven gelation. Biomacromolecules 17: 3648-3658 (2016).
Jamard M, Hoare TR, Sheardown H. Nanogels of methylcellulose hydrophobized with N-tert-butylacrylamide for ocular drug delivery. J Trans Drug Delivery Res 6: 648-659 (2016).
124. Lasowski F, Sheardown H. Atropine and roscovitine release from model silicone hydrogels. Optom Vis Sci. 93: 404-411 (2016).
Deng X, Korogiannaki M, Rastegari B, Zhang J, Chen M, Fu Q, Sheardown H, Filipe C, Hoare T. ‘Click’ Chemistry-Tethered Hyaluronic Acid-Based Contact Lens Coatings Improve Lens Wettability and Lower Protein Adsorption ACS Applied Materials and Interfaces. 8: 22064-22073 (2016).
Prosperi-Porta G, Kedzior S, Muirhead B, Sheardown H. Phenylboronic acid based polymeric micelles for mucoadhesive anterior segment ocular drug delivery. Biomacromolecules 17:1449-1457 (2016).
Korogiannaki M, Guidi G, Jones L, Sheardown H. Timolol maleate release from hyaluronic acid-containing model silicone hydrogel contact lens materials. J Biomater Appl 30:361-376 (2015)
Prosperi-Porta G, Muirhead B, Sheardown H. Tunable release of ophthalmic therapeutics from injectable, resorbable, thermoresponsive copolymer scaffolds. J Biomed Mater Res B 105: 53-62 (2017).
Sheikholeslami P, Baek DS, Muirhead B, Wang H, Zhao H, Sivakumaran D Boyd S, Sheardown H, Hoare TR. Hydrophobically modified poly(vinyl pyrrolidone) as a physically associative, shear responsive ophthalmic hydrogel. Exp Eye Res 137: 18-31 (2015).
Xu F, Sheardown H, Hoare TR. Reactive Electrospinning of Degradable Poly(oligoethylene glycol methacrylate)-Based Nanofibrous Hydrogel Networks. Chem Communications. 52: 1451-1454 (2016).
Rambarran T, Gonzaga F, Brook MA, Lasowksi F, Sheardown H. Amphiphilic elastomers from metal free click crosslinking of PEG-grafted silicone surfactants. J Polym Sci Part A: Polym Chem 53:1082-1093 (2015).
Paterson SM, Liu L, Brook MA, Sheardown H. Poly (ethylene glycol) or silicone modified hyaluronon for contact lens applications. J Biomed Mater Res 103: 2602-2610 (2015).
Amoozgar B, Fitzpatrick SD, Sheardown H. Effect of anti-TGF-beta(2) surface modification of polydimethylsiloxane on lens epithelial cell markers of posterior capsule opacification. Journal of Bioactive and Compatible Polymers 28:637-51 (2015).
Guidi G, Korogiannaki M, Sheardown H. Modification of timolol release from silicone hydrogel model contact lens materials using hyaluronic acid. Eye and Contact Lens 40: 269-276 (2014).
Guidi G, Hughes T, Whinton M, Brook M, Sheardown H. Effect of silicone hydrogel contact lens composition on dexamethasone release. J Biomater Appl 29:222-233 (2014).
Princz MA, Sheardown H, Tethering of epidermal growth factor family members to dendrimer crosslinked collagen gels. J Biomaterials and Tissue Engineering 4:947-956 (2014).
Samsom ML, Morrison S, Masala N, Sullivan BD, Sullivan DA, Sheardown H, et al. Characterization of full-length recombinant human Proteoglycan 4 as an ocular surface boundary lubricant. Experimental Eye Research ;127:14-9 (2014).
Vyner MC, Liu L, Sheardown H, Amsden BG. The effect of elastomer chain flexibility on protein adsorption. Biomaterials 34: 9287-9294 (2013)
Amoozgar B, Morarescu D, Sheardown H. Sulfadiazine modified PDMS as a model lens material with potential for the mitigation of posterior capsule opacification (PCO). Journal of Colloid and Interface Sci B 111: 15-23 (2013).
Mahadevan G, Selvaganapathy P, Sheardown H. PDMS embedded microneedles as a controlled release system for the eye. J Biomater Appl 28: 20-27 (2013).
Weeks AK, Subbaraman LN, Jones L, Sheardown H. Physical entrapment of hyaluronic acid during synthesis results in extended release from model hydrogel and silicone hydrogel contact lens materials. Eye and Contact Lens, 39: 179-185 (2013).
Weeks AK, Boone A, Luensman D, Jones L, Sheardown H. Effects of hyaluronic acid incorporated as a wetting agent on lysozyme denaturation. J Biomater Appl 28: 323-333 (2013).
105. Princz MA, Sheardown H. Modified dendrimer crosslinked collagen based matrices. J Biomater Sci Polym Edn 23 2207-2222 (2012).
So H, Fawcett AS, Sheardown H, Brook MA. Surface-active copolymer formation stabilizes PEG droplets and bubbles in silicone foams. J Coll Inter Sci 390: 121-128 (2013).
Weeks AK, Leusmann D, Boone A, Jones L, Sheardown H. Hyaluronic acid as an internal wetting agent in model DMAA/TRIS contact lenses. J Biomater Appl. 27: 423-432 (2012). NSERC, 20/20
Fitzpatrick SD, Jafar Mazumder MA, Thakur A, Sheardown H. Temperature sensitive polymers for drug delivery. Expert Rev Med Dev 9: 339-351 (2012).
Thakur A, Fitzpatrick S, Zaman A, Kugathasan K, Muirhead B, Hortelano G, Sheardown H. Strategies for ocular siRNA delivery: potential and limitations of non-viral nanocarriers. J Biomedical Engineering. 6: 1-7 (2012).
Weeks AK, Subbaraman L, Jones L, Sheardown H. The competing effects of hyaluronic and methacrylic acid in model contact lenses. J Biomater Sci Polym Edn 23: 1021-1038 (2012). NSERC, 20/20
Weeks AK, Morrison D, Alauzun J, Brook MA, Jones L, Sheardown H. Photocrosslinkable hyaluronic acid as an internal wetting agent in model conventional and silicone hydrogel contact lenses. J Biomed Mater Res 100A 1972-1982 (2012). NSERC, 20/20
Fitzpatrick SD, Jafar Mazumder MA, Muirhead B, Sheardown H. Development of injectable resorbable drug releasing copolymer scaffolds for minimally invasive sustained ophthalmic therapeutics. Acta Biomaterialia 8: 2517-2528 (2012). 20/20, CIHR KT
Princz MA, Sheardown H, Heparin modified dendrimer crosslinked collagen matrices for the delivery of heparin binding epidermal growth factor (HB-EGF). J Biomed Materials Res 100A: 1929-1937 (2012). NSERC
Nguyen D, Hui A, Weeks A, Heynen M, Joyce E, Sheardown H, Jones L, Release of ciprofloxacin-HCl and dexamethasone phosphate by soft contact lens materials loaded with hyaluronic acid, Materials, 5 684-698 (2012).
Jafar Mazumder MA, Fitzpatrick SD, Muirhead B, Sheardown H. Cell-adhesive thermo-gelling PNIPAAm / hyaluronic acid cell delivery hydrogels for non-invasive retinal therapeutics. J Biomed Mater Res A. 100: 1877-1887 (2012).
Hui A, Sheardown H, Jones L, Acetic and acrylic acid molecular imprinted model silicone hydrogel materials for ciprofloxacin-HCL delivery, Materials, 5: 85-107, (2012).
Morrison S, Sullivan DA, Sullivan BD, Sheardown H, Schmidt TA. Dose-dependent and synergistic effects of proteoglycan-4 on boundary layer lubrication at a human cornea polydimethyl siloxane biointerface. Eye and Contact Lens 38: 27-35 (2012).
Wells LA, Sheardown H. Photosensitive controlled release with polyethylene glycol anthracene modified alginate. Eur J Pharm Biopharm. 79: 304-313 (2011).
Ng KK, Awad N, Brook MA, Holloway AC, Sheardown H. Local delivery of nicotine does not mitigate fibrosis but may lead to angiogenesis. J Biomater Appln 26: 349-358 (2011).
Homenick CM, de Silveira G, Sheardown H, Adronov A. Pluronics as crosslinking agents for collagen: novel amphiphilic hydrogels. Polym International 60: 458-465 (2011).
Wells LA, Furukawa S, Sheardown H. Photoresponsive PEG-anthracene grafted hyaluronon as a controlled-delivery biomaterial. Biomacromolecules 12: 923-932 (2011).
Wells LA, Brook MA, Sheardown H. Generic, anthracene based hydrogel crosslinkers for photo-controllable drug delivery. Macromol Biosci 11: 988-998 (2011).
Fitzpatrick SD, Mazumder MAJ, Lasowski F, Fitzpatrick LE, Sheardown H. PNIPAAm-grafted collegen as an injectable in situ gelling bioactive cell delivery scaffold. Biomacromolecules 11:2261-2267 (2010).
Jin ZL, Feng W, Zhu SP, Sheardown H, Brash JL. Protein resistant polyurethane by sequential grafting of poly (2-hydroxyethyl methacrylate) and poly (oligo (ethylene glycol) methacrylate) via surface initiated ATRP. J Biomed Mater Res 95A: 1223-1232 (2010).
Luensmann D, Heynen M, Liu L, Sheardown H, Jones L. Determination of albumin sorption to intraocular lenses by radiolabeling and confocal laser scanning microscopy. J Cataract Refrac Surg 35: 2000-2007 (2009).
Jin ZL, Feng W, Zhu SP, Sheardown H, Brash JL. Protein-resistant polyurethane via surface-initiated atom transfer radical polymerization of oligo(ethylene glycol) methacrylate. J Biomed Mater Res A 91A: 1189-1201 (2009). NSERC Strategic
Morarescu D, West-Mays JA, Sheardown HD. Effect of delivery of MMP inhibitors from PDMS as a model IOL material on PCO markers. Biomaterials 31: 2399-2407 (2010). NSERC Strategic
Gorbet MB, Tanti NC, Jones L, Sheardown H. Corneal epithelial cell biocompatibility to silicone hydrogel and conventional hydrogel contact lens packaging solutions. Mol Vis 16: 272-282 (2010).
Luensmann D, Heynen M, Liu L, Sheardown H, Jones L. The efficiency of contact lens care regimens on protein removal from hydrogel and silicone hydrogel lenses. Mol Vis 16: 79-92 (2010).
Homenick CM, Sheardown H, Adronov A. Reinforcement of collagen with covalently functionalized single-walled carbon nanotube crosslinkers. J Mater Chem 20:2887-2894 (2010).
Alauzun JG, Young S, D’Souza R, Liu L, Brook MA, Sheardown HD. Biocompatible hyaluronic acid modified silicone elastomers. Biomaterials 31: 3471-3478 (2010). NSERC CHRP
Gao X, Feng W, Zhu SP, Sheardown H, Brash JL. Kinetic modeling of surface-initiated atom transfer radical polymerization. Macromol Reaction Eng 4: 235-250 (2010).
Gao X, Zhu SP, Sheardown H, Brash JL. Nanoscale patterning through self-assembly of hydrophilic block copolymers with one chain end constrained to surface. Polymer 51: 1771-1778 (2010).
Klenkler BJ, Dwivedi D, West-Mays JA, Sheardown H. Corneal epithelial cell adhesion and growth on EGF-modified aminated PDMS. J Biomed Mater Res 93A: 1043-109 (2010). NSERC
Prasad BR, Brook MA, Smith T, Zhao SGI, Chen Y, Sheardown H, D’souza R, Rochev Y. Controlling cellular activity by manipulating silicone surface roughness. Coll Surf B:Biointerfaces 78: 237-242 (2010).
Mikhail AS, Ranger JJ, Liu LH, Longenecker R, Thompsom DB, Sheardown HD, Brook MA. Rapid and efficient assembly of functional silicone surfaces protected by PEG: Cell adhesion to peptide modified PDMS. J Biomater Sci Polym Edn 21: 821-842 (2010). NSERC CHRP
Jin ZL, Feng W, Zhu SP, Sheardown H, Brash JL. Protein resistant materials via surface initiated atom transfer radical polymerization of 2-methacryloyloxyethyl phosphorylcholine. J Biomater Sci Polym Edn 21: 1331-1344 (2010).
2000-2009
Gao X, Kucerka N, Nieh MP, Katsaras J, Zhu SP, Brash JL, Sheardown H. Chain conformation of a new class of PEG-based thermoresponsive polymer brushes grafted on silicon as determined by neutron reflectometry. Langmuir 25: 10271-10278 (2009).
Luensmann D, Zhang F, Subbaraman L, Sheardown H, Jones L. Localization of lysozyme sorption to conventional and silicone hydrogel contact lenses using confocal microscopy. Curr Eye Res 34: 683-697 (2009). NSERC
Alauzun JG, Fortuna JN, Sheardown H, Gonzaga F, Brook MA. Generic, S(N)2 reactive silicone surfaces protected by poly(ethylene glycol) linkers: facile routes to new materials. J Mater Chem 19: 5033-5038 (2009). CHRP
Jin ZL, Feng W, Beisser K, Zhu SP, Sheardown H, Brash JL, Protein-resistant polyurethane prepared by surface-initiated atom transfer radical graft polymerization (ATRgP) of water-soluble polymers: Effects of main chain and side chain lengths of grafts. Coll Surf B: Biointerfaces 70: 53-59 (2009).
Subbaraman LN, Glasier MA, Sheardown H, Jones L. Efficacy of an extraction solvent used to quantify albumin deposition on hydrogel contact lens materials. Eye and Contact Lens 35: 76-80 (2009).
Nathu Z, Dwivedi D, Reddan JR, Sheardown H, West-Mays J. Temporal changes in MMP mRNA expression in the lens epithelium during anterior subcapsular cataract formation. Experimental Eye Res 88 323-330 (2009). Strategic
Chow LM, Subbaraman LN, Sheardown H, Jones L. Kinetics of in vitro lactoferrin deposition on silicone hydrogel and FDA group II and group IV contact lenses. J Biomater Sci Polym Edn 20:71-82 (2009).
Benhabbour SR, Sheardown H, Adronov A. Cell adhesion and proliferation on dendronized surfaces. Biomaterials 29: 4177-4186 (2008).
Chen H, Liang W, Zhang Y, McClung G, Brook MA, Sheardown H, Brash JL. Poly (dimethyl siloxane) with fibrinolytic properties. Macromol Biosci 8: 863-870 (2008).
Gao X, Feng W, Zhu S, Sheardown H, Brash JL. A facile method to introduce nanoscale patterns to poly(ethylene glycol) (PEG) surfaces by self-assembly of randomly grafted block copolymer brush. Langmuir 23: 8303-8308 (2008).
Adronov A, Benhabbour S, Sheardown H. Protein resistance of PEG-functionalized dendronized surfaces: Effect of PEG molecular weight and dendron generation. Macromolecules 41:4817-4823 (2008).
Mikhail AS, Jones K, Sheardown H. Dendrimer grafted cell adhesion peptide modified PDMS. Biotech Prog 24: 938-944 (2008).
Princz MA, Sheardown H. Heparin modified dendrimer crosslinked collagen matrices for the delivery of basic fibroblast growth factor (FGF-2). J Biomater Sci Polym Edn 19: 1201-1218 (2008).
van Beek M, Jones L, Sheardown H. Immobilized hyaluronic acid containing model silicone hydrogels reduce protein adsorption. J Biomater Sci Polym Edn 19: 1425-1436 (2008).
Klenkler BJ, Chen H, Brook MA, Liu L, Chen D, West-Mays J, Sheardown H. EGF tethered to polydimethylsiloxane via a high density PEG layer and effects on corneal epithelial cell growth. J Biomater Sci Polym Edn 19: 1411-1424 (2008).
Benhabbour RS, Liu L, Sheardown H, Adronov A. Protein resistance of surfaces prepared by chemisorption of mono-thiolated polyethylene glycol to gold and dendronization with aliphatic polyester dendrons. Macromolecules 41: 2567-2576 (2008).
Duan X, Sheardown H. Incorporation of cell adhesion peptides into collagen scaffolds promotes corneal epithelial stratification. J Biomater Sci Polym Edn 18: 701-707 (2007).
Alibeik S, Sheardown H, Rizkalla A, Mequanint K. Protein adsorption and platelet adhesion onto ion containing polyurethane biomaterials. J Biomater Sci Polym Edn 18: 1195-1210 (2007).
Van Beek M, Jones LW, Sheardown H. Immobilized hyaluronic acid containing hydrogels reduce protein adsorption. Biomaterials 29: 780-789 (2008).
Klenkler BJ, Jones L, Sheardown H. Growth factors in the tear film: Role in tissue maintenance, wound healing and ocular pathology. The Ocular Surface. 5: 228-239 (2007).
Unsworth LD, Sheardown H, Brash JL. Protein resistant PEO grafted surfaces: chain density dependent multiple mechanisms of action. Langmuir 24: 1924-1929 (2008).
Glasier MA, Keech A, Sheardown H, Subbaraman LN, Jones L. Conformational and quantitative characterization of lysozyme extracted from galyfilcon and senofilcon silicone hydrogel contact lenses. Curr Eye Res 33: 1-11 (2008).
Subbaraman L, Glasier M, Sheardown H, Senchyna M, Jones L. Extraction efficiency of extract11ion buffer used to quantify lysozyme deposition on conventional and silicone hydrogel contact lens materials. Eye and Contact Lens 33: 163-173 (2007).
Wells L, Sheardown H. Extended release of high pI proteins from alginate microspheres via a novel encapsulation technique. Eur J Pharm 65: 329-335 (2007).
Klenkler BJ, Sheardown H. Characterization of EGF coupling to aminated silicone rubber surfaces. Biotech Bioeng 95: 1158-1166 (2006).
Friedlaender MH, Breshears D, Amoozgar B, Sheardown H, Senchyna M. The dilution of benzalkonium chloride (BAK) in the tear film. Advances in Therapy. 23: 835-841 (2006).
Tun Z, Unsworth LD, Brash JL, Sheardown H. Determination of graft density of substrate supported polymer films. Physica B. 385-386: 697-699 (2006).
Chen H, Brook MA, Sheardown H. Cell interactions with PDMS surfaces modified with cell adhesion peptides using a generic method. Materials Science Forum. 539-543: 705-709 (2006).
Subbaraman L, Glasier MA, Senchyna M, Sheardown H, Jones LW. Kinetics of in vitro lysozyme deposition on silicone hydrogel, FDA group II and FDA group IV contact lens materials. Curr Eye Res 31: 787-796 (2006).
Duan X, McLaughlin C, Griffith M, Sheardown H. Biofunctionalization of collagen for improved tissue response: scaffolds for artificial cornea. Biomaterials 28: 78-88 (2007).
Subbaraman L, Glasier M, Sheardown H, Senchyna M, Jones L. Rewetting drops containing surface active agents improve the clinical performance of silicone hydrogel contact lenses. Optom Vis Sci 83: 143-151 (2006).
Duan X, Sheardown H. Dendrimer crosslinked collagen as a corneal tissue engineering scaffold: mechanical properties and corneal epithelial cell interactions. Biomaterials 27: 4608-4617 (2006).
Unsworth LD, Tun Z, Sheardown H, Brash JL. In situ neutron reflectometry investigation of gold-chemisorbed PEO layers of varying chain density: relationship of layer structure to protein resistance. J Coll Inter Sci. 296: 520-526 (2005)
Chen H, Brook MA, Sheardown H, Chen Y, Klenkler B. Generic bioaffinity surfaces. Bioconj Chem 17: 21-28 (2006)
Duan X, Klenkler BJ, Sheardown H. Progress in the development of a corneal replacement: keratoprostheses and tissue engineered corneas. Expert Rev Med Dev 3: 59-72 (2006).
Duan X, Sheardown H. Crosslinking of collagen with dendrimers. J Biomed Mater Res 75A: (3): 510-518 (2005).
Mequanint K, Sheardown H. 2-Methacryloyloxyethyl N-butylcarbamate: A new comonomer for hydrogel syntheses with improved hydrophilicity and mechanical properties for ophthalmic applications. J. Biomater Sci Polym Edn. 16: 1303-1318 (2005).
Unsworth LD, Sheardown H., Brash J.L. Effect of chain density, chain length and end group chemistry of poly(ethylene oxide)-thiol thin films adsorption evaluated using immunoblots and Vroman type experiments. Biomaterials 26: 5927-5933 (2005).
Chen H, Chen Y, Sheardown H, Brook MA. Immobilization of heparin on a silicone surface through a PEG spacer. Biomaterials. 26: 7418-7424 (2005).
Suuronen EJ, Sheardown H, Newman K, McLaughlin CR, Griffith M. Building in vitro models of organs. Intl Rev Cytol. 244: 139-175 (2005).
Unsworth LD, Sheardown H, Brash JL. Protein resistance of surfaces prepared by sorption of end thiolated poly (ethylene glycol) to gold: Effect of surface chain density. Langmuir 21: 1036-1041 (2005).
Klenkler BJ, Griffith M, Beceril C, West-Mays J, Sheardown H. EGF grafted surfaces in artificial corneal applications. Biomaterials. 26:7286-7296 (2005)
Chen H, Zhang Z, Chen Y, Brook MA, Sheardown H. Protein repellant silicone surfaces by covalent immobilization of poly (ethylene oxide). Biomaterials. 26: 2391-2399 (2005).
Chen H, Brook MA, Chen Y, Sheardown H. Surface properties of PEO silicone composites: controlling protein adsorption. J Biomater Sci Polym Edn 16:531-538 (2005).
Unsworth LD, Tun Z, Sheardown H, Brash JL. Chemisorption of thiolated poly (ethylene oxide) to gold: surface chain densities measured by ellipsometry and neutron reflectometry. J Colloid Inter Sci 281: 112-121 (2005).
Chen H, Zhang Z, Chen Y, Brook MA, Sheardown H. Protein repellant silicone surfaces by covalent immobilization of poly (ethylene oxide). Biomaterials. 26: 2391-2399 (2004).
Liu L, Sheardown H. Polydimethylsiloxane poly (N-isopropyl acrylamide) network polymers as ophthalmic biomaterials. Biomaterials 26: 233-244 (2005).
Ragheb A, Chen H, Marshall ML, Hrynyk M, Sheardown H, Brook MA. Controlling protein deposition at silicone elastomer interfaces. American Chemical Society Division of Polymer Chemistry. U423 (2004).
King M, Duan X, Sheardown H. Modified dendrimers for hydrophobic toxin removal. Biotech Bioeng. 86: 512-519 (2004).
Li F, Griffith M, Lohmann C, Li C, Tanodekaew S, Sheardown H, Hakim M, Carlsson DJ. Preparation and characterization of bio-synthetic polymer matrices to promote recruitment of multiple cell lines: functional corneal regeneration. Biomaterials. 26: 3093-3401 (2005).
Klenkler BJ, Sheardown H. Growth factors in the anterior segment: role in tissue maintenance, wound healing and ocular pathology. Exp Eye Res 79: 677-688 (2004).
Unsworth LD, Tun Z, Sheardown H, Brash JL. Chemisorption of thiolated poly (ethylene oxide) to gold: surface chain densities measured by ellipsometry and neutron reflectometry. J Colloid Inter Sci 281: 112-121 (2005).
Chen H, Brook MA, Sheardown H. Silicone elastomers for reduced protein adsorption. Biomaterials. 25: 2273-2282 (2004).
Li F, Carlsson DJ, Lohmann CP, Suuronen EJ, Vascotto SG, Kobuch K, Sheardown HD, Munger R, Nakamura M, Griffith M., Cellular and nerve regeneration within a bio-synthetic extracellular matrix for corneal transplantation. Proc Natl Acad Sci U.S.A. 100: 15346-15351 (2003).
Merrett K, Griffith CM, Deslandes Y, Pleizier G, Dubé MA, Sheardown H. Interactions of corneal cells with TGF-2 modified silicone rubber surfaces. J Biomed Mater Res. 67A: 981-993 (2003).
Griffith M, Hakim M, Shimmura S, Watsky MA, Li F, Carlsson D, Nakamura M, Suuronen E, Shinozaki N, Nakata K, Sheardown H. Artificial corneas: scaffolds for transplantation and host regeneration. Cornea 21: S54-S61 (2002).
Duan X, Griffith CM, Dubé MA, Sheardown H. Novel dendrimer based polyurethanes for PEO incorporation. J Biomater Sci Polym Edn 13:667-690 (2002).
Merrett K, Cornelius RM, McClung WG, Unsworth LD, Sheardown H. Surface analysis methods for characterizing polymeric biomaterials. J Biomater Sci Polym Edn, 13: 593-622 (2002)
Aucoin L, Griffith CM, Deslandes Y, Pleizier G, Sheardown H. Interactions of corneal epithelial cells with cell adhesion peptide combinations on PDMS surfaces. J Biomater Sci Polym Edn 13: 447-462 (2002).
McCormick H, McMillan R, Merrett K, Bensebaa F, Deslandes Y, Sheardown H. XPS and water contact angle evaluation of the effect of conditions of peptide chemisorption to gold and silver coated polymer surfaces. Colloids and Surfaces B: Biointerfaces. 26: 351-363 (2002).
Merrett K, Griffith CM, Deslandes Y, Pleizier G, Sheardown H. Adhesion of corneal epithelial cells to cell adhesion peptide modified pHEMA surfaces. J Biomater Sci Polym Edn 12(6) 647-671 (2001).
Woods DR, Kourti T, Wood PE, Sheardown H, Crowe CM, Dickson JM. Assessing problem solving skills II. Chem Eng Education 36(1) 60-67 (2002).
Woods DR, Wood PE, Sheardown H, Kourti T. Assessing problem solving skills. Chem Eng Education 35(4) 300-307 (2001).
McMillan R, Meeks B, Bensebaa F, Deslandes Y, Sheardown H. Cell adhesion peptide modification of gold coated polyurethanes for vascular endothelial cell adhesion. J Biomed Mater Res 54: 272-283 (2001).
Sun X, Sheardown H, Tengvall P, Brash JL, Peptide modified gold-coated polyurethanes as thrombin scavenging surfaces. J Biomed Mater Res 49: 66-78 (2000).
1993-1999
Sheardown H, Cornelius R, and Brash JL. Measurement of protein adsorption to metals using radioiodination methods: a caveat. Colloids and Surfaces B: Biointerfaces 10: 29-33 (1997).
Sheardown H, Clark C, Wedge C, Apel R, Rootman DS, Cheng Y-L. A semi solid drug delivery system for epidermal growth factor in corneal epithelial wound healing. Curr Eye Res 16: 183-190, 1997.
Sheardown H, Cheng Y-L. Mechanisms of corneal epithelial wound healing. Chem Eng Sci 51: 4517-4529, 1996.
Sheardown H, Cheng Y-L., EGF in tears following corneal epithelial wound creation. J Ocular Pharm Thera 12: 239-243, 1996.
Trope GE, Cheng, Y-L, Sheardown H, Liu GS, Menon IA, Heathcote JG, Rootman DS, Chiu WJ Gould L. Depot drug delivery system for 5-fluorouracil after filtration surgery in the rabbit. Can J Ophthalmol 29: 263-267, 1994.
Gould L, Trope G, Cheng Y-L, Rootman DS, Heathcote JG, Sheardown H, Liu GS, Menon IA. 50:50 poly (DL glycolic acid - lactic acid) copolymer as a drug delivery system for 5-fluorouracil: a histopathological evaluation. Can J Ophthalmol 29: 168-171, 1994.
Sheardown H, Wedge C, Chou L, Apel R, Rootman DS, Cheng Y-L. Continuous EGF delivery in corneal epithelial wound healing. Invest Ophthalmol Vis Sci 34: 3593-3600, 1993.